TB is truly one of the major public health concerns, with transmission dynamics being quite complex and very much influenced by anthropological factors. Specifically, in this research paper, the researcher investigates the social and cultural backgrounds that shape TB transmission by exploring how human behavior, cultural beliefs, and socioeconomic factors interconnect to preserve the spread of the TB disease. In the depth of available literature review and ethnographic fieldwork, this study exposes complex anthropological dynamics that sustain the transmission of TB, showing how social and cultural factors call for a more nuanced understanding. Focal group discussions were how the researcher used to work. Among the main findings brought out by the researcher include the cultural beliefs and practices that influence health-seeking behavior and socioeconomic factors. The research shows that anthropological insight is indispensable in the development of effective, culturally sensitive interventions in the struggle against tuberculosis.