Review: Drug Dissolution and Solubility

http://dx.doi.org/10.31703/giidr.2018(III-I).02      10.31703/giidr.2018(III-I).02      Published : Fall 2018
Authored by : Najam ul Hassan , Maria Naz Bakhtiari , Dur E Nayab , Gul Shahnaz

02 Pages : 8-12

http://dx.doi.org/10.31703/giidr.2018(III-I).02      10.31703/giidr.2018(III-I).02      Published : Dec 2018

Review: Drug Dissolution and Solubility

Abstract

    The review's goals are to: a) provide a clear overview of current solubility and dissolution science, b) describe common technologies for assessing solubility and dissolution, and c) recommend the best practice technique. The theories of solubility and dissolution that are required in drug development have been examined, with an emphasis on oral absorption. Dissolution had been elaborated with the equation. Low-water solubility drugs have slow rates of dissolving, which leads to issues with oral bioavailability. Insufficient bioavailability is frequently caused by poorly water-soluble medicines' weak solubility and slow rate of dissolution in aqueous gastrointestinal fluids. Noyes Whitney's equation has been discussed and elaborated in this review. Solubility concepts are revised. Significance points of both dissolution and solubility are related to the oral absorption of drugs.

    Dissolution, Solubility, Oral Drug Delivery

    (1) Najam ul Hassan
    Pharm-D, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Maria Naz Bakhtiari
    M.phil, Department of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan.
    (3) Dur E Nayab
    M.phil, Department of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan.
    (4) Gul Shahnaz
    Associate Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan
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APA

CHICAGO

    CHICAGO : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. 2018. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review, III (I): 8-12 doi: 10.31703/giidr.2018(III-I).02

HARVARD

    HARVARD : HASSAN, N. U., BAKHTIARI, M. N. & NAYAB, D. E. 2018. Review: Drug Dissolution and Solubility. Global Immunological & Infectious Diseases Review, III, 8-12.

MHRA

    MHRA : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. 2018. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review, III: 8-12

MLA

    MLA : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review, III.I (2018): 8-12 Print.

OXFORD

    OXFORD : Hassan, Najam ul, Bakhtiari, Maria Naz, and Nayab, Dur E (2018), "Review: Drug Dissolution and Solubility", Global Immunological & Infectious Diseases Review, III (I), 8-12

TURABIAN

    TURABIAN : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review III, no. I (2018): 8-12. https://doi.org/10.31703/giidr.2018(III-I).02