02 Pages : 8-12
http://dx.doi.org/10.31703/giidr.2018(III-I).02 10.31703/giidr.2018(III-I).02 Published : Dec 2018Review: Drug Dissolution and Solubility
The review's goals are to: a) provide a clear overview of current solubility and dissolution science, b) describe common technologies for assessing solubility and dissolution, and c) recommend the best practice technique. The theories of solubility and dissolution that are required in drug development have been examined, with an emphasis on oral absorption. Dissolution had been elaborated with the equation. Low-water solubility drugs have slow rates of dissolving, which leads to issues with oral bioavailability. Insufficient bioavailability is frequently caused by poorly water-soluble medicines' weak solubility and slow rate of dissolution in aqueous gastrointestinal fluids. Noyes Whitney's equation has been discussed and elaborated in this review. Solubility concepts are revised. Significance points of both dissolution and solubility are related to the oral absorption of drugs.
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Dissolution, Solubility, Oral Drug Delivery
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(1) Najam ul Hassan
Pharm-D, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
(2) Maria Naz Bakhtiari
M.phil, Department of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan.
(3) Dur E Nayab
M.phil, Department of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan.
(4) Gul Shahnaz
Associate Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan
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Cite this article
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APA : Hassan, N. u., Bakhtiari, M. N., & Nayab, D. E. (2018). Review: Drug Dissolution and Solubility. Global Immunological & Infectious Diseases Review, III(I), 8-12. https://doi.org/10.31703/giidr.2018(III-I).02
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CHICAGO : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. 2018. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review, III (I): 8-12 doi: 10.31703/giidr.2018(III-I).02
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HARVARD : HASSAN, N. U., BAKHTIARI, M. N. & NAYAB, D. E. 2018. Review: Drug Dissolution and Solubility. Global Immunological & Infectious Diseases Review, III, 8-12.
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MHRA : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. 2018. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review, III: 8-12
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MLA : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review, III.I (2018): 8-12 Print.
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OXFORD : Hassan, Najam ul, Bakhtiari, Maria Naz, and Nayab, Dur E (2018), "Review: Drug Dissolution and Solubility", Global Immunological & Infectious Diseases Review, III (I), 8-12
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TURABIAN : Hassan, Najam ul, Maria Naz Bakhtiari, and Dur E Nayab. "Review: Drug Dissolution and Solubility." Global Immunological & Infectious Diseases Review III, no. I (2018): 8-12. https://doi.org/10.31703/giidr.2018(III-I).02