The production of successful and promising innovation in pharmaceutical and clinical care delivery is subjected to factual and efficient clinical trials. The most crucial step for a successful trial is dependent on subject participation. The extent of subject participation has a high impact on the conclusions of a trial. The biggest challenges with the conventional trials are patient enrollment and retention, inefficiency, costly and time-consuming methods. A new concept of digitalizing the clinical research process, ‘Virtual Clinical Trials’ (VCTs), has captured the attention of researchers with its phenomenal time and cost-saving attributes along with the advantage of data collection from multiple sources, ease of access to restricted study sites breaking the location barriers, increased patient retention and automated data collection. The concept of virtual trials is not fully explored yet and seems to face various challenges but is expected to revolutionize the methods of clinical research with its potential benefits.